What Is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell and is essential for energy production, DNA repair, and cellular signaling. Although not a peptide, it is frequently discussed alongside longevity therapies.
How It Works
NAD+ participates in mitochondrial ATP production and serves as a substrate for sirtuins and PARP enzymes involved in cellular repair and healthy aging.
Potential Benefits Being Studied
Healthy aging, fatigue, mitochondrial disorders, neurodegeneration, metabolic health, recovery, and cognitive function.
Typical Research Dosing
Protocols differ by route and indication. Oral precursors, IV infusion, and injectable formulations have all been studied.
Administration
Research includes IV, intramuscular, subcutaneous, oral precursor, and intranasal approaches depending on the study.
Possible Side Effects
Flushing, nausea, chest tightness during rapid infusion, headache, fatigue, and injection-site discomfort.
Bottom Line
NAD+ is central to cellular metabolism and remains an active area of longevity and mitochondrial research.